Osteoarthritis is believed to affect millions of American, thus,
making it one of the largest bone diseases in the United States today,
revealed by online sources. However, researchers conducting the
large-scale studies said that a person’s genetic factor may play a role
in developing osteoarthritis, says an article at
ncl.ac.uk/press.office/press.release/item/new-study-finds-genetic-causes-of-osteoarthritis.
This discovery may be regarded to be a significant development in
understanding the link between the genetic factor and the development of
the disease. Osteoarthritis is a medical condition which is represented
by breakdown of the cartilages.Inherited genetic factors may increase
your risk of developing osteoarthritis by 50 percent.
Because osteoarthritis is considered to run in families, the
osteoarthritis genes are continued to go on to the next generation,
rather than their shared environment, Researchers, who are studying the
many genetic features, may easily recognize the people at higher risk of
developing osteoarthritis, such as those people whose risk factors
include family history of osteoarthritis, hormonal changes, injury or
obesity. The genetic regions, which may be the potential major risk
factor that causes the development of osteoarthritis, are identified
with great confidence by the researchers in the study.This considered as
an essential first step.
Although the precise function of many of these genetic risk factors
remains unclear, it seems that they largely act by altering the function
of chondrocytes, which are the cells involved in the production and
maintenance of articular cartilage. It is considered that during the
start of the formation of the cartilage, these alterations are observed;
when subtle alterations in cell function may affect characteristics
such as overall joint shape.Further work is now needed to pinpoint the
actual DNA changes within the genetic regions to establish exactly how
these changes lead to osteoarthritis. Moreover, other genetic variants
remained to be discovered, according to researchers, and that it
involved far more genes in susceptibility to osteoarthritis than was
thought.
There are only limited to non-surgical treatment options, such as
pain relievers and physiotherapy until joint replacement becomes a
viable option. The brand DePuy is one of the most popular hip
replacement devices.Specifically, experts say, tiny fragments of metal
shear off from these artificial joints, causing chronic pain or
infection and raising levels of metal in the bloodstream. To understand
more about this matter, more information are offered at
depuyhiprecallnewscenter.com
References:
news-medical.net/news/20130702/Osteoarthritis-associated-genes-an-interview-with-Professor-Jonathan-Tobias-University-of-Bristol.aspx
arthrolink.com/en/osteoarthritis-folders/all-folders/genetics-and-osteoarthritis-0
arthritisresearchuk.org/news/press-releases/2012/july/major-new-study-finds-clues-to-the-genetic-causes-of-osteoarthritis.aspx
ncl.ac.uk/press.office/press.release/item/new-study-finds-genetic-causes-of-osteoarthritis
sciencedaily.com/releases/2010/09/100921084539.htm
manchester.ac.uk/aboutus/news/archive/list/item/?id=8463&year=2012&month=07
bbc.co.uk/news/health-18676893
